Homophilic interaction of the L1 family of cell adhesion molecules
نویسندگان
چکیده
منابع مشابه
Cryo-electron tomography of homophilic adhesion mediated by the neural cell adhesion molecule L1.
The neural cell adhesion molecule L1 participates in homophilic interactions important for axon guidance and neuronal development. The structural details of homophilic adhesion mediated by L1 and other immunoglobulin superfamily members containing an N-terminal horseshoe arrangement of four immunoglobulin-like domains are unknown. Here we used cryo-electron tomography to study liposomes to whic...
متن کاملNeuromuscular target recognition by a homophilic interaction of connectin cell adhesion molecules in Drosophila.
Drosophila Connectin (CON) is a cell surface protein of the leucine-rich repeat family. During the formation of neuromuscular connectivity, CON is expressed on the surface of a subset of embryonic muscles and on the growth cones and axons of the motoneurons that innervate these muscles, including primarily SNa motoneurons and their synaptic targets (lateral muscles). In vitro, CON can mediate h...
متن کاملCancer cells cut homophilic cell adhesion molecules and run.
The term contact inhibition (CI) encompasses the cellular changes that result in cessation of cell migration and of proliferation due to signals transduced when one cell comes into physical contact with another cell. Cancer cells, however, do not contact inhibit. A molecular understanding of the loss of CI in cancer cells is important for understanding tumor progression. In this Perspective, we...
متن کاملBrain development in mice lacking L1–L1 homophilic adhesion
A new mouse line has been produced in which the sixth Ig domain of the L1 cell adhesion molecule has been deleted. Despite the rather large deletion, L1 expression is preserved at normal levels. In vitro experiments showed that L1-L1 homophilic binding was lost, along with L1-alpha5beta1 integrin binding. However, L1-neurocan and L1-neuropilin binding were preserved and sema3a responses were in...
متن کاملThe intracellular interactions of the L1 family of cell adhesion molecules.
The L1 family of CAMs (cell adhesion molecules) has long aroused the interest of researchers, but primarily the extracellular interactions of these proteins have been elucidated. More recently, attention has turned to the intracellular signalling potentiated by transmembrane proteins and the cytoplasmic proteins with which they can interact. The present review brings up to date the current body...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2012
ISSN: 1226-3613,2092-6413
DOI: 10.3858/emm.2012.44.7.050